In part 2, we continue our conversation with Dr. James Pfaus, behavioral neuroscientist and Assistant Professor at Charles University in Prague.
We explore what current research does and does not show about THC and CBD for pelvic and sexual health, and why so much of what we know still comes from self-reported experiences rather than large clinical trials. Dr. Pfaus explains how dose, delivery method, and individual sensitivity all shape effects on discomfort, arousal, and pleasure.
We also talk about placebo responses, drug interactions, and why cannabis products with known, consistent dosing matter for both clinicians and patients. Listeners will learn how clinicians might think through “start low, test thoughtfully” strategies, why route of administration changes onset and intensity, and where carefully documented case series could move the science forward.
In this episode, you will hear:
- How THC and CBD may affect pelvic discomfort and sexual response
- Why most current knowledge comes from case reports instead of large clinical trials
- Dose finding with gummies and other formats using a “self-experiment” approach
- Differences between oral, rectal, vaginal, and inhaled administration
- Placebo effects in sexual medicine versus studies on physical discomfort
- Risks of dependence, withdrawal, and mixing cannabis with other substances
Resources from this Episode
- Effects of Cannabinoids on Female Sexual Function — PubMed: https://pubmed.ncbi.nlm.nih.gov/31521567/?utm_source=chatgpt.com
- ACOG: Cannabis Products for Pain Associated With Gynecologic Conditions: https://www.acog.org/clinical/clinical-guidance/clinical-consensus/articles/2024/07/the-use-of-cannabis-products-for-the-management-of-pain-associated-with-gynecologic-conditions?utm_source=chatgpt.com
- IASP: Cannabis, Cannabinoids and Pain Management Research Agenda: https://pmc.ncbi.nlm.nih.gov/articles/PMC8855877/?utm_source=chatgpt.com
- Cannabis and Male Sexual Function — PubMed: https://pubmed.ncbi.nlm.nih.gov/32561331/?utm_source=chatgpt.com
- Medical Cannabis/Cannabinoids for Chronic Pain — BMJ: https://www.bmj.com/content/374/bmj.n1034?utm_source=chatgpt.com
Disclaimer:
The information shared in this podcast is intended for educational and informational purposes only and should not be considered medical advice. It is not intended to diagnose, treat, cure, or prevent any disease or medical condition. The views and opinions expressed are those of the individual participants and do not necessarily reflect the views, policies, or positions of MedRoots or the medical community at large. Listeners should consult a qualified healthcare professional before making any healthcare-related decisions.
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